Bodeutsch C, de Wilde P C, Kater L, Hené R J, van den Hoogen F H, van de Putte L B, Vooijs G P
Department of Pathology, University Hospital Nijmegen, Netherlands.
Neth J Med. 1992 Apr;40(3-4):148-57.
Labial salivary gland histopathology has long been considered to be the most disease-specific single test for diagnosis of Sjögren's syndrome. However, the diagnostic yield of widely used grading systems of focal lymphocytic sialoadenitis is rather low. Determination of the percentages IgA-, IgG-, IgM-, kappa-, and lambda-containing plasma cells in minor salivary glands obtained from a lower lip biopsy has recently been shown to be extremely valuable in Sjögren's syndrome, not only for diagnosis, but also for prognosis with regard to the development of systemic monoclonal lymphoproliferative disease. This technique greatly improves the value of labial salivary gland biopsy in Sjögren's syndrome.
长期以来，唇唾液腺组织病理学一直被认为是诊断干燥综合征最具疾病特异性的单项检查。然而，广泛使用的局灶性淋巴细胞性涎腺炎分级系统的诊断阳性率相当低。最近研究表明，对下唇活检获取的小唾液腺中含IgA、IgG、IgM、κ和λ浆细胞的百分比进行测定，在干燥综合征中极具价值，不仅有助于诊断，还能对系统性单克隆淋巴细胞增殖性疾病的发展进行预后判断。这项技术极大地提高了唇唾液腺活检在干燥综合征中的价值。
