Bornstein Michael M, Lys Oliver, Altermatt Hans Jörg, Stauffer Edouard, Buser Daniel
Klinik für Oralchirurgie und Stomatologie, Zahnmedizinische Kliniken der Universität Bern.
Schweiz Monatsschr Zahnmed. 2005;115(6):542-8.
In this retrospective study, charts were analyzed of 94 patients who presented with oral squamous cell carcinoma (OSCC) at the Department of Oral Surgery and Stomatology at the University of Bern from 1990 to 2002. Critical points in the evaluation included presence and type of potential noxious agents, tumor size and palpable lymph nodes at the first oral cancer examination, and the delay (patient and professional delay) from the appearance of the first clinical signs to the definitive diagnosis. Of the patients included, 56 patients were smokers, 48 patients reported regular consumption of alcoholic beverages, and 41 patients had a combination of smoking and drinking habits. Invasion of neighbouring tissues by the OSCCs (= cT4), mainly into alveolar bone, was found in 25 cases, and 35 patients already had clinically suspicious lymph nodes upon examination (cN1-cN3). The total delay until the definitive diagnosis "OSCC" was between two (median) and five months (mean). These results suggest that further efforts in primary and secondary OSCC prevention programs, such as smoking cessation and screening of patients at risk, are necessary to optimize the longterm prognosis and to minimize morbidity of patients suffering from OSCC.
在这项回顾性研究中,对1990年至2002年期间在伯尔尼大学口腔外科和口腔医学系就诊的94例口腔鳞状细胞癌(OSCC)患者的病历进行了分析。评估的关键点包括潜在有害因素的存在和类型、首次口腔癌检查时的肿瘤大小和可触及的淋巴结,以及从首次临床症状出现到最终确诊的延迟时间(患者延迟和专业延迟)。在纳入的患者中,56例为吸烟者,48例报告经常饮用酒精饮料,41例有吸烟和饮酒的综合习惯。25例OSCC患者出现邻近组织侵犯(=cT4),主要侵犯牙槽骨,35例患者在检查时已有临床可疑淋巴结(cN1 - cN3)。直至最终确诊为“OSCC”的总延迟时间为2个月(中位数)至5个月(平均值)。这些结果表明,有必要在原发性和继发性OSCC预防项目中进一步努力,如戒烟和对高危患者进行筛查,以优化长期预后并将OSCC患者的发病率降至最低。