[甲硫硫平敏感的5-羟色胺受体参与了福寿螺逃避反应敏感化的突触后机制]

[Methiothepin-sensitive serotonin receptors are involved in postsynaptic mechanism of sensitization of Helix lucorum escape reaction].

作者信息

Abramova M S, Nistratova V L, Moskvitin A A, Pivovarov A S

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 2005 May-Jun;55(3):385-92.

Abstract

Tetanic electric stimulation of Helix foot evokes sensitization of escape reaction. This behavioral sensitization and posttetanic potentiation (PTP) of acetylcholine-induced inward current (ACh-current) in command Helix neurons of escape behavior were similar. Antagonist of serotonin receptors methiothepin prevents the PTP of the ACh-current and behavioral sensitization. Serotonin disrupts the PTP of the ACh-current. It is suggested that the increase in cholinosensitivity of the command neurons with the involvement of methiothepin-sensitive serotonin receptors may be the cellular postsynaptic mechanism of behavioral sensitization of Helix escape reaction.

摘要

对耳螺足部进行强直电刺激会引发逃避反应的敏感化。这种行为敏感化与逃避行为的指令耳螺神经元中乙酰胆碱诱导的内向电流（ACh电流）的强直后增强（PTP）相似。5-羟色胺受体拮抗剂美噻吨可阻止ACh电流的PTP和行为敏感化。5-羟色胺会破坏ACh电流的PTP。有人提出，在对美噻吨敏感的5-羟色胺受体参与下，指令神经元胆碱敏感性的增加可能是耳螺逃避反应行为敏感化的细胞突触后机制。