Cai Junchao, Terasaki Paul I
Terasaki Foundation Laboratory, 11570 West Olympic Boulevard, Los Angeles, CA, 90064, USA.
Surg Today. 2005;35(8):605-12. doi: 10.1007/s00595-005-3015-6.
Human leukocyte antigen (HLA) antibody-mediated hyperacute rejection has dramatically decreased since the clinical introduction of crossmatch technology. However, the role of HLA antibody in acute and chronic rejection remains unclear. In this article, we cite publications to show the correlation between HLA antibody and allograft rejection. Potential pathological mechanisms of antibody-mediated rejection are also proposed and the rationale of commonly used HLA antibody detection techniques are introduced. The advantages and disadvantages of these technologies are further discussed in detail. We conclude that owing to the recent availability of improved antibody detection methods, a causal relationship between HLA antibodies and allograft rejection is now considered to exist.
自从临床引入交叉配型技术以来，人类白细胞抗原（HLA）抗体介导的超急性排斥反应已显著减少。然而，HLA抗体在急性和慢性排斥反应中的作用仍不清楚。在本文中，我们引用文献来展示HLA抗体与同种异体移植排斥反应之间的相关性。还提出了抗体介导的排斥反应的潜在病理机制，并介绍了常用的HLA抗体检测技术的基本原理。进一步详细讨论了这些技术的优缺点。我们得出结论，由于最近改进的抗体检测方法的出现，现在认为HLA抗体与同种异体移植排斥反应之间存在因果关系。
