Ophir A, Ticho U
Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel.
Ophthalmic Surg. 1992 May;23(5):339-41.
Filtering bleb encapsulation (BE) involves fibroblast proliferation and collagen synthesis. We analyzed the effect of 5-fluorouracil (5-FU) on the inhibition of BE. Forty-one patients with primary open-angle glaucoma underwent trabeculectomy in one eye as an initial surgery. Twenty-one of these eyes, randomly chosen, were treated postoperatively with four to six 5-FU subconjunctival injections over 10 days to inhibit bleb scarring; the remaining 20 eyes did not receive 5-FU. After 12 to 24 months, the surgical success rate was significantly higher in the treated eyes (P less than .05). However, the incidence of BE was similar: two eyes (9.5% and 10%, respectively) in each group. The difference between the effect of 5-FU in the inhibition of BE and bleb scarring suggests that the characteristics of the two fibroblast populations are heterogeneous.
滤过泡包裹（BE）涉及成纤维细胞增殖和胶原蛋白合成。我们分析了5-氟尿嘧啶（5-FU）对BE的抑制作用。41例原发性开角型青光眼患者接受了一眼小梁切除术作为初始手术。其中随机选择的21只眼在术后10天内接受4至6次5-FU结膜下注射以抑制滤过泡瘢痕形成；其余20只眼未接受5-FU治疗。12至24个月后，治疗组的手术成功率显著更高（P小于0.05）。然而，BE的发生率相似：每组各有两只眼（分别为9.5%和10%）。5-FU在抑制BE和滤过泡瘢痕形成方面的效果差异表明，两种成纤维细胞群体的特征是异质性的。
