一项基于人群的孤立性眼裂缺损病例对照研究。

A population-based case-control study of isolated ocular coloboma.

作者信息

Vogt Gábor, Puhó Erzsébet, Czeizel Andrew E

机构信息

Hospital and Central Outpatients Clinics of the Hungarian State Railways, Podmaniczky u. 111, H-1062 Budapest, Hungary.

出版信息

Ophthalmic Epidemiol. 2005 Jun;12(3):191-7. doi: 10.1080/09286580590969699.

DOI:10.1080/09286580590969699

PMID:16036478

Abstract

AIMS

To attempt the detection of possible etiological factors in the origin of isolated ocular, mainly iris coloboma.

METHODS

The data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-2002, was used. Exposure data and family history were based on (1) prospective medical records, (2) retrospective maternal information, and (3) information obtained by regional nurses at home visit.

RESULTS

Of 46 cases, 40 were affected with iris coloboma and 19 had bilateral manifestation. The positive family history indicated a hereditary origin in 4.3% (2/46) of cases. An association was found between the isolated ocular coloboma and hydroxyethylrutoside treatment (adjusted POR with 95% CI: 5.4, 2.2-12.9). Another association was seen between isolated ocular coloboma and hypothyroidism (adjusted OR with 95% CI = 12.6, 3.0-52.7), but it was based only on two cases.

CONCLUSIONS

It is necessary to study the preventable environmental factors in the origin of these ocular defects.

摘要

目的

尝试检测孤立性眼部疾病（主要为虹膜缺损）发病的可能病因。

方法

使用1980 - 2002年匈牙利先天性异常病例对照监测数据集。暴露数据和家族史基于（1）前瞻性医疗记录、（2）回顾性母亲信息以及（3）地区护士家访获得的信息。

结果

46例病例中，40例患有虹膜缺损，19例为双侧表现。阳性家族史表明4.3%（2/46）的病例有遗传起源。发现孤立性眼部缺损与羟乙基芦丁治疗之间存在关联（校正后POR及95%可信区间：5.4，2.2 - 12.9）。孤立性眼部缺损与甲状腺功能减退之间也存在关联（校正后OR及95%可信区间 = 12.6，3.0 - 52.7），但仅基于两例病例。