Iemma F, Spizzirri U G, Puoci F, Muzzalupo R, Trombino S, Picci N
Dipartimento di Scienze Farmaceutiche, Università della Calabria, Rende, Italy.
Drug Deliv. 2005 Jul-Aug;12(4):229-34. doi: 10.1080/10717540590952690.
The aim of this research is the preparation of acryloylated bovine serum albumin microspheres and the evaluation of their employment in drug delivery. The influence of preparation parameters on albumin microspheres and the chemicophysical properties of loaded drugs were investigated. In particular, we focused our attention on acylation albumin degree, amount of acryloylated albumin against comonomer in the polymerization step, and finally the release profile. We considered on the interaction drug-matrix, the fuctionalization degree of albumin, and the water affinity of matrix.
