Tramontano A, Lesk A M
Istituto di Ricerche di Biologia Molecolare, Pomezia, Roma, Italy.
Proteins. 1992 Jul;13(3):231-45. doi: 10.1002/prot.340130306.
Using database screening techniques we have examined the relationship between antigen-binding loops in immunoglobulins, and regions of similar conformation in other protein families. The conformations of most antigen-binding loops are not unique to immunoglobulins. But in many cases, the geometrical relationship between the loop and the peptides flanking it differs between the immunoglobulins and other structures with the same loop. We assess model building by data base screening, compared with that based on canonical structures.
利用数据库筛选技术，我们研究了免疫球蛋白中抗原结合环与其他蛋白质家族中相似构象区域之间的关系。大多数抗原结合环的构象并非免疫球蛋白所特有。但在许多情况下，免疫球蛋白与具有相同环的其他结构之间，环与其侧翼肽之间的几何关系有所不同。我们通过数据库筛选评估模型构建，并与基于标准结构的模型构建进行比较。
