de Almeida Sergio Monteiro, Rebelatto Carmen Lúcia Kuniyoshi, Queiroz-Telles Flavio, Werneck Lineu Cesar
Neurology Unit, Hospital de Clínicas, Federal University of Paraná, Especialidade de Neurologia, Rua General Carneiro, 181, sala 1236, 80060-900 Curitiba, PR, Brazil.
J Infect. 2005 Aug;51(2):140-3. doi: 10.1016/j.jinf.2004.06.008.
Paracoccidioidomycosis (PCM) is a chronic granulomatous infectious disease, whose etiologic agent is the fungus Paracoccidioides brasiliensis. The central nervous system (CNS) involvement with paracoccidioidomycosis (NPCM) occurs more frequently than has been admitted in the past. There are some major histocompatibility complex antigen association studies with systemic paracoccidioidomycosis. Some indicate a positive association with HLA antigens, but there is no study with the involvement of the CNS. To investigate why not all cases of systemic PCM show the involvement of the CNS and whether genetic factors are involved, we studied 6 patients with NPCM, from the neuroinfection outpatient clinic. The patients were typed for class I and class II antigens by a microlymphocytoxity standard test. The HLA antigen frequencies found in this study in patients with NPCM were not different from the alleles frequencies observed in the Paraná population.
副球孢子菌病（PCM）是一种慢性肉芽肿性传染病，其病原体是巴西副球孢子菌。中枢神经系统（CNS）受累的副球孢子菌病（NPCM）比过去所公认的更为常见。有一些关于系统性副球孢子菌病的主要组织相容性复合体抗原关联研究。一些研究表明与人类白细胞抗原（HLA）抗原呈正相关，但尚无关于中枢神经系统受累情况的研究。为了探究为何并非所有系统性PCM病例都会出现中枢神经系统受累以及遗传因素是否参与其中，我们对神经感染门诊的6例NPCM患者进行了研究。通过微淋巴细胞毒性标准试验对患者的I类和II类抗原进行分型。本研究中NPCM患者的HLA抗原频率与巴拉那人群中观察到的等位基因频率并无差异。
