精神分裂症患者脑脊液中嗜铬粒蛋白A样免疫反应性：与快速眼动睡眠潜伏期和慢波睡眠的关系

CSF chromogranin A-like immunoreactivity in schizophrenia: relationships with REM latency and slow wave sleep.

作者信息

van Kammen D P, O'Connor D T, Neylan T C, Mouton A, Gurklis J A, Gilbertson M W, Peters J L

机构信息

Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA.

出版信息

Psychiatry Res. 1992 Apr;42(1):53-63. doi: 10.1016/0165-1781(92)90038-5.

DOI:10.1016/0165-1781(92)90038-5

PMID:1603881

Abstract

Chromogranin A (CgA) is a calcium binding protein and a precursor of modulatory peptides in the brain. We measured CgA-like immunoreactivity (CgA-LI) in cerebrospinal fluid (CSF) in 15 male schizophrenic patients (diagnosed by DSM-III-R criteria) after 3 nights of polysomnography. Patients had been drug free for at least 33 days. Our earlier report that CSF CgA-LI in schizophrenic patients correlated significantly with negative symptoms and ventricle-brain ratios, which have been related to slow wave sleep, raised the possibility that CgA-LI might relate to slow wave sleep. CSF CgA-LI was significantly correlated with stage 4 sleep and rapid eye movement latency. Whether these positive relationships between CSF CgA-LI and electroencephalographic sleep measures are specific for schizophrenia awaits further study.

摘要

嗜铬粒蛋白A（CgA）是一种钙结合蛋白，也是大脑中调节肽的前体。我们对15名男性精神分裂症患者（根据DSM-III-R标准诊断）进行了3晚多导睡眠图检查后，测量了他们脑脊液（CSF）中的嗜铬粒蛋白A样免疫反应性（CgA-LI）。患者至少33天未服用药物。我们之前的报告指出，精神分裂症患者脑脊液中的CgA-LI与阴性症状及脑室-脑比率显著相关，而这些又与慢波睡眠有关，这就增加了CgA-LI可能与慢波睡眠相关的可能性。脑脊液CgA-LI与4期睡眠和快速眼动潜伏期显著相关。脑脊液CgA-LI与脑电图睡眠指标之间的这些正相关关系是否是精神分裂症所特有的，还有待进一步研究。