快速眼动睡眠剥夺对大鼠下丘脑前列腺素的影响。

Effect of rapid-eye-movement sleep deprivation on rat hypothalamic prostaglandins.

作者信息

Gelir Ethem, Arslan Seyfullah Oktay, Sayan Hale, Pinar Lamia

机构信息

Department of Physiology, Zonguldak Karaelmas University Medical School, Kozlu, Turkey.

出版信息

Prostaglandins Leukot Essent Fatty Acids. 2005 Nov;73(5):391-6. doi: 10.1016/j.plefa.2005.05.021.

DOI:10.1016/j.plefa.2005.05.021

PMID:16039105

Abstract

In this study, we investigated thyroid hormones, thyroid stimulating hormone (TSH), prostaglandin D(2) (PGD(2)) and prostaglandin E(2) (PGE(2)) levels in rapid-eye-movement (REM) sleep-deprived rats compared with controls. The aim of the present study was to detect the effect of REM sleep deprivation (RSD) especially on hypothalamic prostaglandin levels. Twenty-seven male rats were randomly assigned in three groups as dry cage control, yoked control, and RSD. RSD rats were sleep deprived for 10 consecutive days. At the end of 10th day all rats were sacrificed for measurement. Our results indicated that total triiodothyronine (T(3)) and thyroxine (T(4)) decreased in the RSD group while there was no change in TSH. We also measured hypothalamic PGD(2) and PGE(2) levels, but we could not find any significant change between groups.

摘要

在本研究中，我们调查了快速眼动（REM）睡眠剥夺大鼠与对照组相比的甲状腺激素、促甲状腺激素（TSH）、前列腺素D2（PGD2）和前列腺素E2（PGE2）水平。本研究的目的是检测REM睡眠剥夺（RSD）对下丘脑前列腺素水平的影响，尤其是对其的影响。27只雄性大鼠被随机分为三组：干笼对照组、配对对照组和RSD组。RSD组大鼠连续10天被剥夺睡眠。在第10天结束时，所有大鼠均被处死以进行测量。我们的结果表明，RSD组的总三碘甲状腺原氨酸（T3）和甲状腺素（T4）降低，而TSH没有变化。我们还测量了下丘脑PGD2和PGE2水平，但未发现各组之间有任何显著变化。