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新型吖啶亚基和亚苄基噻唑烷二酮的合成及其生物活性

Synthesis and biological activity of novel acridinylidene and benzylidene thiazolidinediones.

作者信息

Mourão R H, Silva T G, Soares A L M, Vieira E S, Santos J N, Lima M C A, Lima V L M, Galdino S L, Barbe J, Pitta I R

机构信息

Departamento de Antibioticos, Universidade Federal de Pernambuco, Centro de Ciências Biológicas, 50670-901 Recife, Brasil.

出版信息

Eur J Med Chem. 2005 Nov;40(11):1129-33. doi: 10.1016/j.ejmech.2005.06.002. Epub 2005 Aug 29.

DOI:10.1016/j.ejmech.2005.06.002
PMID:16040159
Abstract

A novel set of acridinylidene thiazolidinediones and benzylidene thiazolidinediones was synthesized by nucleophilic addition of cyanoacrylates. Some of these compounds were evaluated for their glucose lowering capability and their effects on the triglyceride level in alloxan diabetic mice.

摘要

通过氰基丙烯酸酯的亲核加成反应合成了一组新型的吖啶亚基噻唑烷二酮和亚苄基噻唑烷二酮。对其中一些化合物在四氧嘧啶糖尿病小鼠中的降血糖能力及其对甘油三酯水平的影响进行了评估。

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