Olesen Anne Braae, Bang Karen, Juul Svend, Thestrup-Pedersen Kristian
Department of Dermatology, University Hospital of Aarhus, P.P. Ørumsgade 11, DK-8000 Aarhus C, Denmark.
Acta Derm Venereol. 2005;85(3):244-7. doi: 10.1080/00015550510026343.
An increase in the prevalence of atopic dermatitis (AD) has been reported since the 1960s. The increase could be due to many factors including a genuine increase of incidence or duration of AD. We decided to study if the increasing trend persisted during the 1990s by comparing the cumulative incidence of AD in 1993 and 1998. Further, we studied the severity and management of AD among children. Two samples of children born in Denmark were drawn from the Danish Medical Birth Register. In the 1993 and 1998 studies a mailed questionnaire with identical questions concerning AD was sent out. In the 1998 follow-up study the questionnaire included a severity score and questions concerning management of AD. In the 1993 study the cumulative incidence of AD at age 7 was 18.9% and in 1998 it was 19.6%. There was no difference in the age-adjusted AD incidence in the 5-year observation period. In the 1998 study, 81% had mild to moderate AD, 90% had been seen by a doctor at least once, 36% had mainly been treated by a dermatologist, and 2% had been hospitalized. It should be kept in mind that we base most of our common knowledge of the disease on AD patients selected for management in dermatology clinics and departments.
自20世纪60年代以来,已有报道称特应性皮炎(AD)的患病率有所上升。这种上升可能是由于多种因素,包括AD发病率或病程的真正增加。我们决定通过比较1993年和1998年AD的累积发病率,研究这种上升趋势在20世纪90年代是否持续。此外,我们还研究了儿童AD的严重程度和治疗情况。从丹麦医疗出生登记处抽取了两组丹麦出生儿童样本。在1993年和1998年的研究中,发放了一份关于AD的问题相同的邮寄问卷。在1998年的随访研究中,问卷包括严重程度评分和关于AD治疗的问题。在1993年的研究中,7岁时AD的累积发病率为18.9%,1998年为19.6%。在5年观察期内,年龄调整后的AD发病率没有差异。在1998年的研究中,81%的患者患有轻度至中度AD,90%的患者至少看过一次医生,36%的患者主要由皮肤科医生治疗,2%的患者曾住院治疗。应该记住的是,我们对该疾病的大多数常识是基于在皮肤科诊所和科室接受治疗的AD患者。