[迈内特基底核实验性损伤的神经生物化学]
[Neurobiochemistry of experimental lesions of the basal nucleus of Meynert].
作者信息
Reine G, Nieoullon A
机构信息
Unité de neurochimie, CNRS, Marseille.
出版信息
Rev Neurol (Paris). 1992;148(1):24-38.
Lesions of the nucleus basalis magnocellularis (of Meynert) in rats induce severe cognitive impairments, in both mnesic and attentional functions. During the last 10 years, many studies tended to establish some relationships between the behavioral and biochemical effects of such lesions. Recent data show that the activity of some peptidergic and glutamaterigic neurons in target areas is modified by cholinergic deafferentation. A new physiological interpretation may be proposed for the associated cognitive deficits.
大鼠（迈内特）基底核大细胞部的损伤会导致严重的认知障碍，包括记忆和注意力功能方面。在过去十年中，许多研究倾向于确立此类损伤的行为和生化效应之间的一些关系。最近的数据表明，胆碱能去传入作用会改变靶区域中一些肽能和谷氨酸能神经元的活性。对于相关的认知缺陷，可能会提出一种新的生理学解释。
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