Lema Cristina L, Cisterna Daniel M, Freire Maria Cecilia
Servicio de Neurovirosis, Instituto Nacional de Enfermedades Infecciosas, ANLIS-Dr. Carlos G. Malbrán, Buenos Aires, Argentina.
Medicina (B Aires). 2005;65(3):196-200.
The aim of this study was to assess the prevalence of adenovirusm (ADV) infections in neurological disorders. A total of 108 cerebrospinal fluid (CSF) samples from 79 encephalitis cases, 7 meningitis and 22 other neurological diseases analysed in our laboratory between 2000 and 2002 were studied. Forty nine (47.4%) belonged to immunocompromised patients. Viral genome was detected using nested polymerase chain reaction (Nested-PCR) and ADV genotypes were identified using partial gene sequence analysis of hexon gene. Adenovirus were detected in 6 of 108 (5.5%) CSF samples tested. All of these were from encephalitis cases, 6/79, representing 7.6% of them. No statistically significant differences were observed (p > 0.05) between the immunocompromised and non immunocompromised patients with ADV infection of the central nervous system. Two ADV genotypes (B1 and C) were identified. In conclusion, our results describe the role of ADV in neurologic infections in Argentina. The results contribute to the knowledge of ADV epidemiology, specially in encephalitis.
本研究旨在评估腺病毒（ADV）感染在神经系统疾病中的患病率。对2000年至2002年间在我们实验室分析的79例脑炎病例、7例脑膜炎和22例其他神经系统疾病的108份脑脊液（CSF）样本进行了研究。其中49例（47.4%）属于免疫功能低下患者。使用巢式聚合酶链反应（Nested-PCR）检测病毒基因组，并通过六邻体基因的部分基因序列分析鉴定ADV基因型。在检测的108份CSF样本中有6份（5.5%）检测到腺病毒。所有这些样本均来自脑炎病例，6/79，占脑炎病例的7.6%。在免疫功能低下和非免疫功能低下的中枢神经系统ADV感染患者之间未观察到统计学上的显著差异（p>0.05）。鉴定出两种ADV基因型（B1和C）。总之，我们的结果描述了ADV在阿根廷神经系统感染中的作用。这些结果有助于了解ADV的流行病学，特别是在脑炎方面。
