早期蛋白质聚集过程中过氧化氢的产生：不同神经退行性疾病中的一种常见病理机制？
The production of hydrogen peroxide during early-stage protein aggregation: a common pathological mechanism in different neurodegenerative diseases?
作者信息
Tabner B J, Turnbull S, Fullwood N J, German M, Allsop D
机构信息
Magnetic Resonance Laboratory, University of Lancaster, Lancaster LA1 4YQ, UK.
出版信息
Biochem Soc Trans. 2005 Aug;33(Pt 4):548-50. doi: 10.1042/BST0330548.
PMID:16042541
Abstract
By means of an ESR spin-trapping method, we have shown that Abeta (amyloid beta), alpha-synuclein and various toxic forms of the prion protein all appear to generate H2O2 in vitro. A fundamental molecular mechanism underlying the pathogenesis of cell death in several different neurodegenerative diseases could be the direct production of H2O2 during the early stages of protein aggregation.
摘要
通过电子自旋共振（ESR）自旋捕集法，我们已经表明，β-淀粉样蛋白（Aβ）、α-突触核蛋白以及朊病毒蛋白的各种毒性形式在体外似乎都会产生过氧化氢（H₂O₂）。几种不同神经退行性疾病中细胞死亡发病机制的一个基本分子机制可能是在蛋白质聚集的早期阶段直接产生H₂O₂。
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