创伤性脑损伤患者血清蛋白S100b的动态变化及其临床意义

Dynamic change of serum protein S100b and its clinical significance in patients with traumatic brain injury.

作者信息

Chen Da-qing, Zhu Lie-lie

机构信息

Department of Neurosurgery, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, China.

出版信息

Chin J Traumatol. 2005 Aug;8(4):245-8.

PMID:16042873

Abstract

OBJECTIVE

To analyze the dynamic change of serum protein S100b in patients with traumatic brain injury and its clinical value in assessing brain damage.

METHODS

According to Glasgow coma scale (GCS), 102 cases of traumatic brain injury were divided into mild brain injury group (GCS > or = 13, n = 31, Group A), moderate brain injury group (8 < GCS < 13, n = 37, Group B) and severe brain injury group (GCS < or = 8, n = 34, Group C). Serial S100b concentrations were analyzed by enzyme-linked immunosorbent assay (ELISA) in blood samples taken on admission, 12 h, 24 h, 48 h, 72 h and 7 days after traumatic brain injury.

RESULTS

The severe brain injury group showed significantly higher concentration of serum S100b, with earlier increase and longer duration, than the mild and moderate brain injury groups. The patients with higher S100b exhibited lower GCS scores and poor clinical prognosis. The increase in S100b could emerge before clinical image evidence indicated so.

CONCLUSIONS

Serum S100b can be used as a sensitive index for assessment and prediction of traumatic brain injury severity and prognosis.

摘要

目的

分析创伤性脑损伤患者血清蛋白S100b的动态变化及其在评估脑损伤中的临床价值。

方法

根据格拉斯哥昏迷量表（GCS），将102例创伤性脑损伤患者分为轻度脑损伤组（GCS≥13，n = 31，A组）、中度脑损伤组（8＜GCS＜13，n = 37，B组）和重度脑损伤组（GCS≤8，n = 34，C组）。采用酶联免疫吸附测定法（ELISA）分析创伤性脑损伤后入院时、伤后12小时、24小时、48小时、72小时和7天采集的血样中S100b的系列浓度。