Andreadis Dimitrios, Epivatianos Apostolos, Poulopoulos Athanasios, Nomikos Alexandros, Christidis Konstantinos, Papazoglou Georgios, Antoniades Demetrios, Barbatis Calypso
Department of Oral Medicine and Maxillofacial Pathology, Dental School, Aristotle University of Thessaloniki, Greece.
Oral Oncol. 2005 Sep;41(8):799-805. doi: 10.1016/j.oraloncology.2005.03.007.
The study of the expression of cell adhesion molecules (CAMs), E-cadherin, desmoglein-2, beta4-integrin, HCAM (CD44s) and ICAM-1 in Warthin's tumours. Twenty formalin--fixed, paraffin--embedded parotid Warthin's tumours were studied using an Envision/HRP immunohistochemical technique. Beta4-integrin was strongly expressed in all cell-basement membrane and intercellular contacts of the epithelium, E-cadherin and desmoglein-2 in cell-cell contacts, but not in basal cell-basement membrane connections and on columnar cells' luminal surfaces, HCAM (CD44s) in intercellular contacts of both luminal (mainly), basal cells and also in the periphery of monocytic-lymphocytic stroma, and ICAM-1 was weak to moderate expressed in both luminal and basal epithelial cells and strongly in the germinal lymphocytic centres. CAM expression suggests a bilayered excretory ductal structure of the neoplastic epithelium in Warthin's tumour, as a result of hyperplastic process of the glandular epithelium that interacts with the excessive lymphoid tissue of the stroma.
沃辛瘤中细胞黏附分子（CAMs）、E-钙黏蛋白、桥粒芯糖蛋白-2、β4整合素、HCAM（CD44s）和细胞间黏附分子-1（ICAM-1）表达的研究。采用Envision/HRP免疫组织化学技术对20例福尔马林固定、石蜡包埋的腮腺沃辛瘤进行研究。β4整合素在上皮细胞的所有细胞-基底膜和细胞间接触部位均有强烈表达，E-钙黏蛋白和桥粒芯糖蛋白-2在细胞-细胞接触部位表达，但在基底细胞-基底膜连接部位及柱状细胞的腔面不表达，HCAM（CD44s）在管腔（主要是）、基底细胞的细胞间接触部位以及单核细胞-淋巴细胞性间质的周边均有表达，ICAM-1在管腔和基底上皮细胞中呈弱阳性至中度表达，在生发淋巴细胞中心呈强表达。CAM的表达提示沃辛瘤中肿瘤上皮具有双层排泄导管结构，这是腺上皮增生过程与间质中过多淋巴组织相互作用的结果。
