Pooga Margus, Langel Ulo
Estonian Biocentre, Tartu.
Methods Mol Biol. 2005;298:77-89. doi: 10.1385/1-59259-877-3:077.
Cell-penetrating peptides (CPPs) have served as vehicles for the delivery of different molecules and particles into cells. The efficiency and noninvasive nature of peptide-mediated cellular transduction provides a promising tool for biomedical research. Studies of cell-penetrating constructs that deliver oligonucleotides, peptides, and proteins have elucidated several important cellular signaling mechanisms. Here we briefly describe the major classes of cell-penetrating peptides. We also present various strategies used to couple different cargoes to CPPs.
细胞穿透肽（CPPs）已成为将不同分子和颗粒递送至细胞内的载体。肽介导的细胞转导的高效性和非侵入性为生物医学研究提供了一种很有前景的工具。对递送寡核苷酸、肽和蛋白质的细胞穿透构建体的研究阐明了几种重要的细胞信号传导机制。在此，我们简要描述细胞穿透肽的主要类别。我们还介绍了用于将不同货物与CPPs偶联的各种策略。
