葡萄糖转运蛋白1在食管鳞状细胞癌中的过表达：预后不良的一个标志物。

Overexpression of glucose transporter 1 in esophageal squamous cell carcinomas: a marker for poor prognosis.

作者信息

Tohma T, Okazumi S, Makino H, Cho A, Mochizuki R, Shuto K, Kudo H, Matsubara K, Gunji H, Matsubara H, Ochiai T

机构信息

Department of Academic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.

出版信息

Dis Esophagus. 2005;18(3):185-9. doi: 10.1111/j.1442-2050.2005.00489.x.

DOI:10.1111/j.1442-2050.2005.00489.x

PMID:16045581

Abstract

Recently, Glut1 (human erythrocyte glucose transporter) expression has been demonstrated in various tumors. The aim of this study is to evaluate the prognostic utility of Glut1 expression in esophageal carcinomas. We studied Glut1 expression by immunohistochemistry of paraffin sections from 63 esophageal squamous cell carcinomas. All 63 carcinomas expressed Glut1. The mean percentage of positively stained tumor cells was 77.8% (median, 84.7%). There were two staining patterns in positive cells: 'strongly positive' and 'weakly positive'. The percentage of 'strongly positive' cells (%Glut1-SP) ranged from 0% to 95.6% (mean, 32.3%; median, 27.4%). The 5-year survival rate for patients with a high %Glut1-SP (> 30%) was significantly lower than that for patients with a low %Glut1-SP (< 30%) (P < 0.01). Statistical analysis revealed that the relative risk of death for patients with high %Glut1-SP was 2.02 times that for patients with low %Glut1-SP (P = 0.064), suggesting a possible independent predictive value for %Glut1-SP.

摘要

最近，已证实葡萄糖转运蛋白1（人类红细胞葡萄糖转运体）在多种肿瘤中均有表达。本研究旨在评估葡萄糖转运蛋白1在食管癌中的预后价值。我们通过免疫组化方法研究了63例食管鳞状细胞癌石蜡切片中葡萄糖转运蛋白1的表达情况。63例癌组织均表达葡萄糖转运蛋白1。肿瘤细胞阳性染色的平均百分比为77.8%（中位数为84.7%）。阳性细胞有两种染色模式：“强阳性”和“弱阳性”。“强阳性”细胞的百分比（%Glut1-SP）范围为0%至95.6%（平均为32.3%；中位数为27.4%）。%Glut1-SP高（>30%）的患者5年生存率显著低于%Glut1-SP低（<30%）的患者（P<0.01）。统计分析显示，%Glut1-SP高的患者死亡相对风险是%Glut1-SP低的患者的2.02倍（P = 0.064），提示%Glut1-SP可能具有独立的预测价值。