Chang Chia-Chu, Hung Ching-Hui, Yen Chaun-Shu, Hwang Kai-Lin, Lin Ching-Yuang
Department of Pediatrics, Children's Hospital, Chunghua Christian Hospital, 135 Nan-Shiao Street, Changhua 500, Taiwan.
Nephrol Dial Transplant. 2005 Oct;20(10):2172-7. doi: 10.1093/ndt/gfi011. Epub 2005 Jul 26.
Inadequate plasma ghrelin levels determine the suppression of appetite, nutritional state and morbidity. We investigated the correlation between plasma ghrelin levels and appetite, nutritional status and cardiovascular morbidity in maintenance haemodialysis (HD) patients.
We measured plasma ghrelin levels at 2 h intervals during a 24 h period in 22 non-diabetic HD patients, who were grouped into normal intake or disturbed intake according to subjective global assessments, and in six healthy controls.
A significant positive correlation existed between the 24 h plasma ghrelin profile and most time-specific plasma ghrelin levels in non-diabetic HD patients. Ghrelin levels in the abnormal intake group were higher than those in the normal intake group. A significant positive correlation existed between ghrelin and left ventricle functions, including left ventricle mass index (r = 0.75, P = 0.008), left ventricle mass (r = 0.57, P = 0.03) and interventricular septum thickness (r = 0.70, P = 0.009). An inverse correlation existed between plasma ghrelin and right ventricular dimension (r = -0.45, P = 0.035). Body mass index (r = -0.64, P = 0.033) and body fat content (r = -0.619, P = 0.002) had significant negative correlations with plasma ghrelin.
Anorexia was found in patients with higher plasma ghrelin levels. Plasma ghrelin levels in non-diabetic HD patients showed a significant correlation with left ventricular function.
血浆胃饥饿素水平不足会影响食欲、营养状况和发病率。我们研究了维持性血液透析（HD）患者血浆胃饥饿素水平与食欲、营养状况及心血管疾病发病率之间的相关性。
我们对22名非糖尿病HD患者在24小时内每隔2小时测量一次血浆胃饥饿素水平，这些患者根据主观全面评估分为正常摄入量组或摄入量紊乱组，并选取了6名健康对照者进行同样测量。
非糖尿病HD患者24小时血浆胃饥饿素曲线与大多数特定时间的血浆胃饥饿素水平之间存在显著正相关。摄入量异常组的胃饥饿素水平高于正常摄入量组。胃饥饿素与左心室功能之间存在显著正相关，包括左心室质量指数（r = 0.75，P = 0.008）、左心室质量（r = 0.57，P = 0.03）和室间隔厚度（r = 0.70，P = 0.009）。血浆胃饥饿素与右心室尺寸呈负相关（r = -0.45，P = 0.035）。体重指数（r = -0.64，P = 0.033）和体脂含量（r = -0.619，P = 0.002）与血浆胃饥饿素呈显著负相关。
血浆胃饥饿素水平较高的患者存在厌食情况。非糖尿病HD患者的血浆胃饥饿素水平与左心室功能显著相关。
