Frabasile S, Vitureira N, Perez G, Mateos S, Arbiza J
Sección Virología, Facultad de Ciencias, Universidad de la República, Iguá 4225., Montevideo, Uruguay.
Acta Virol. 2005;49(2):129-32.
Adenoviruses are one of the most frequent causative agents of acute lower respiratory infections in infants and young children. Twenty-three adenovirus isolates from nasopharyngeal aspirates of children hospitalized for acute lower respiratory infections in Uruguay between 1994 and 1998 were studied by restriction enzyme analysis. The genomic analysis showed that 60.9% (n = 14) of isolates belonged to the species Human adenovirus C (HAdV-C) and 31.9% (n = 9) to the species Human adenovirus B (HAdV-B). Whereas some isolates could be classified according to the published profiles into genotype or genomic variant, others displayed migration patterns not allowing classification. Eight isolates (89%) of HAdV-B corresponded to the Ad7h genotype that has been associated with severe and fatal pneumonia and necrotizing bronchiolitis in children in South America. The isolates of HAdV-C showed a great variability in accordance with the data published earlier.
腺病毒是婴幼儿急性下呼吸道感染最常见的病原体之一。对1994年至1998年期间在乌拉圭因急性下呼吸道感染住院的儿童鼻咽抽吸物中分离出的23株腺病毒进行了限制性酶切分析。基因组分析表明，60.9%（n = 14）的分离株属于人腺病毒C（HAdV-C）种，31.9%（n = 9）属于人腺病毒B（HAdV-B）种。虽然一些分离株可以根据已发表的图谱分类为基因型或基因组变体，但其他分离株显示出无法分类的迁移模式。8株（89%）HAdV-B分离株对应于Ad7h基因型，该基因型与南美洲儿童的严重和致命性肺炎及坏死性细支气管炎有关。HAdV-C分离株与早期发表的数据一致，显示出很大的变异性。
