Kajon A E, Mistchenko A S, Videla C, Hortal M, Wadell G, Avendaño L F
Departamento de Microbiologia, Universidad de Buenos Aires, Argentina.
J Med Virol. 1996 Feb;48(2):151-6. doi: 10.1002/(SICI)1096-9071(199602)48:2<151::AID-JMV6>3.0.CO;2-8.
A collection of 165 adenovirus strains isolated from nasopharyngeal aspirates of children hospitalized for acute lower respiratory infection in Argentina, Chile, and Uruguay between 1991 and 1994 was studied by restriction enzyme analysis (work performed in the Department of Virology, University of Umeå). Of the isolates, 71% (n = 117) were identified as members of subgenus B. Of these, 101 (61.2%) corresponded to genome type 7h, four (2.4%) to genome type 3p2, four (2.4%) to genome type 11a, one (0.6%) to genome type 7b, and one (0.6%) to genome type 7c. Two isolates that were neutralized as serotype 3 and four isolates that were neutralized as serotype 7 exhibited novel BamHI cleavage profiles corresponding to three new genome types denominated 3x, 7i, and 7j. Subgenus C members represented 28.5% of all typed isolates. Five different genome types of Ad1, seven genome types of Ad2, and three genome types of Ad5 were identified of, which two, two, and one, respectively, were found to correspond to new DNA variants. Only one isolate (0.6%) corresponded to Ad4 of subgenus E. Ad7h was isolated from 17 of the 18 fatal cases recorded among the patients included in the study.
对1991年至1994年期间从阿根廷、智利和乌拉圭因急性下呼吸道感染住院儿童的鼻咽抽吸物中分离出的165株腺病毒进行了限制性酶切分析研究（该研究工作在于默奥大学病毒学系开展）。在这些分离株中，71%（n = 117）被鉴定为B亚属成员。其中，101株（61.2%）对应基因组类型7h，4株（2.4%）对应基因组类型3p2，4株（2.4%）对应基因组类型11a，1株（0.6%）对应基因组类型7b，1株（0.6%）对应基因组类型7c。两株被中和为血清型3的分离株和4株被中和为血清型7的分离株表现出新型的BamHI酶切图谱，对应三种新的基因组类型，分别命名为3x、7i和7j。C亚属成员占所有分型分离株的28.5%。鉴定出了Ad1的五种不同基因组类型、Ad2的七种基因组类型和Ad5的三种基因组类型，其中分别有两种、两种和一种被发现对应新的DNA变体。只有一株分离株（0.6%）对应E亚属的Ad4。在该研究纳入的患者记录的18例死亡病例中，有17例分离出了Ad7h。
