Yaghoubian Bahareh, Ngo Binh, Mak May, Ostrzega Enrique, Tesoro Jane, Mitani Gladys H Moriguchi
Ambulatory Care Pharmacy, University of Southern California School of Pharmacy, Los Angeles, CA 90033, USA.
Cutis. 2005 Jun;75(6):329-38.
Skin reactions associated with oral coumarin-derived anticoagulants are an uncommon occurrence. Leukocytoclastic vasculitis (LV) is primarily a cutaneous small vessel vasculitis, though systemic involvement may be encountered. We report 4 patients with late-onset LV probably due to warfarin. All 4 patients presented with skin eruptions that developed after receiving warfarin for several years. The results of skin lesion biopsies were available in 3 patients, confirming LV Cutaneous lesions resolved in all patients after warfarin was discontinued. In 2 of the 4 patients, rechallenge with warfarin led to recurrence of the lesions. LV may be a late-onset adverse reaction associated with warfarin therapy.
与口服香豆素类抗凝剂相关的皮肤反应并不常见。白细胞破碎性血管炎（LV）主要是一种皮肤小血管炎，不过也可能出现全身受累情况。我们报告了4例可能由华法林导致的迟发性LV患者。所有4例患者均在接受华法林治疗数年之后出现皮肤疹。3例患者有皮肤病变活检结果，证实为LV。停用华法林后，所有患者的皮肤病变均消退。4例患者中有2例再次使用华法林后病变复发。LV可能是与华法林治疗相关的迟发性不良反应。
