Li Philip Kam-Tao, Chow Kai Ming
Division of Nephrology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong.
Perit Dial Int. 2005 Feb;25 Suppl 3:S80-3.
This article reviews the clinical aspects of and epidemiological links between vascular mortality and the dialysis population, and emphasizes areas that warrant further clarification. In particular, we highlight potential pitfalls in interpretation of published observational and clinical studies, notably some of the issues related to reverse epidemiology of risk factors for cardiovascular disease. Recent published data from our own center in the Prince of Wales Hospital relating to the significance of residual renal function, inflammation, valvular calcification, as well as left ventricular hypertrophy were highlighted. Actions are needed to tackle both the traditional and the nontraditional factors for cardiovascular disease in order to treat this problem causing the highest mortality in peritoneal dialysis patients.
本文回顾了血管性死亡率与透析人群之间的临床情况及流行病学联系，并强调了需要进一步阐明的领域。特别是，我们突出了已发表的观察性和临床研究在解读方面的潜在陷阱，尤其是一些与心血管疾病危险因素的反向流行病学相关的问题。我们还强调了威尔士亲王医院我们自己中心最近发表的有关残余肾功能、炎症、瓣膜钙化以及左心室肥厚意义的数据。需要采取行动应对心血管疾病的传统和非传统因素，以治疗导致腹膜透析患者死亡率最高的这一问题。
