Schünemann H, Willich N
Onkologische Klinik, Abteilung Gynäkolgie, Westfälischen Wilhelms-Universität Münster.
Zentralbl Chir. 1992;117(4):220-5.
1107 cases of lymphedema of the ipsilateral arm (27%) were found in 4011 female breast cancer patients suffered from 4101 breast cancer, seen in the Bad Trissl hospital between 1972 and 1990. The right arm was affected in 47.5%, the left in 52.5%. Primary treatment had consisted of operation alone in 1630 patients with a consecutive rate of edema of 20.3%. Additional irradiation increased this rate up to 31.4% (n = 2471). The rate of edema after radical mastectomy (n = 731), modified radical mastectomy (n = 3149) and breast preserving operation (n = 221) were 39.2% and 9.5% respectively. Adjuvant radiotherapy increased the edema rate of each the surgical procedures (radical mastectomy alone 22.7%, with irradiation 44.7%, modified radical mastectomy alone 19.9%, with irradiation 29.3%, breast preserving operation alone 6.9%, with irradiation 10.4%). During the observation time from 1972 to 1990, the edema rate was reduced from 38% to 18%, reflecting the change of the chosen therapy modalities (radical surgery and conventional irradiation from the 50th's to the early 70th's, breast preserving techniques with modern megavoltage irradiation in the late 80th's). A further reduction of the lymphedema rates by minimization of the aggressiveness of the treatment seems to be possible and should be taken into account for preserving an optimal quality of life.
1972年至1990年期间,在巴特特里塞尔医院对4011例患有4101例乳腺癌的女性乳腺癌患者进行了研究,发现其中1107例(27%)出现同侧手臂淋巴水肿。右臂受累占47.5%,左臂占52.5%。1630例患者的初始治疗仅为手术,水肿发生率为20.3%。额外放疗使该发生率升至31.4%(n = 2471)。根治性乳房切除术(n = 731)、改良根治性乳房切除术(n = 3149)和保乳手术(n = 221)后的水肿发生率分别为39.2%和9.5%。辅助放疗增加了每种手术方式的水肿发生率(单纯根治性乳房切除术22.7%,放疗后44.7%;单纯改良根治性乳房切除术19.9%,放疗后29.3%;单纯保乳手术6.9%,放疗后10.4%)。在1972年至1990年的观察期内,水肿发生率从38%降至18%,这反映了所选治疗方式的变化(从50年代到70年代初的根治性手术和传统放疗,到80年代后期的保乳技术及现代兆伏放疗)。通过尽量减少治疗的侵袭性来进一步降低淋巴水肿发生率似乎是可行的,并且为了保持最佳生活质量应予以考虑。