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Gestational exposure to hydroxyprogesterone caproate suppresses reproductive potential in male rats.

作者信息

Pushpalatha T, Reddy P Ramachandra, Reddy P Sreenivasula

机构信息

Department of Biotechnology, S.V. University, 517 502, Tirupati, India.

出版信息

Naturwissenschaften. 2005 Aug;92(8):385-8. doi: 10.1007/s00114-005-0005-x. Epub 2005 Oct 25.

DOI:10.1007/s00114-005-0005-x
PMID:16049688
Abstract

Hydroxyprogesterone caproate was administered to pregnant rats at a dose level of 10 and 25 mg/kg body weight on 1st, 7th and 14th gestational day and the male pups (F1 generation) were allowed to grow for 90 days. The effect of gestational exposure to hydroxyprogesterone caproate on fertility was assessed by breeding F1 male rats with control female rats besides analyzing sperm quality and quantity in F1 male rats. The number of implantation sites and viable fetuses was significantly reduced in females mated with F1 males that were exposed to hydroxyprogesterone caproate during embryonic development. The decrease in sperm function was associated with a decrease in sperm motility, sperm viability and sperm count in F1 rats. The study clearly indicates that in utero exposure to hydroxyprogesterone caproate affects fertility in male rats.

摘要

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本文引用的文献

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Naturwissenschaften. 2004 May;91(5):242-4. doi: 10.1007/s00114-004-0521-0. Epub 2004 Apr 16.
2
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Naturwissenschaften. 2003 Jan;90(1):40-3. doi: 10.1007/s00114-002-0384-1. Epub 2002 Dec 20.
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己酸羟孕酮注射液降低早产风险的疗效、安全性及患者可接受性的批判性评价
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