Zakhary Kristina, Ellis David A F
University of Toronto, Department of Otolaryngology-Head and Neck Surgery, Toronto, Ontario, Canada.
Facial Plast Surg. 2005 May;21(2):110-6. doi: 10.1055/s-2005-872411.
Photodynamic therapy (PDT) using aminolevulinic acid (ALA) is a promising new technique that is being studied extensively and used in a variety of cosmetic facial plastic arenas. These applications include U.S. Food and Drug Administration-approved treatment of premalignant and malignant skin conditions, as well as off-label uses for photorejuvenation, and the treatment of acne vulgaris, sebaceous gland hyperplasia, rosacea, and hirsutism. This article reviews the interplay of factors that contribute to the appearance of actinically damaged or photoaged skin, also known as dermatoheliosis. This is followed by a brief review of the mechanisms of action of ALA-based PDT and some of its cosmetic facial plastic uses.
使用氨基乙酰丙酸（ALA）的光动力疗法（PDT）是一项很有前景的新技术，目前正在被广泛研究，并应用于各种面部整形美容领域。这些应用包括美国食品药品监督管理局批准的对皮肤癌前病变和恶性病变的治疗，以及用于光嫩肤、寻常痤疮、皮脂腺增生、酒渣鼻和多毛症的非标签用途。本文综述了导致光损伤或光老化皮肤（也称为皮肤光化性弹力纤维病）外观的各种因素之间的相互作用。接下来简要回顾基于ALA的PDT的作用机制及其在面部整形美容方面的一些应用。
