Gold Michael H, Goldman Mitchel P
Gold Skin Care Center, Nashville, Tennessee 37215, USA.
Dermatol Surg. 2004 Aug;30(8):1077-83; discussion 1083-4. doi: 10.1111/j.1524-4725.2004.30331.x.
Photodynamic therapy, utilizing the topical administration of 20% 5-aminolevulinic acid, has generated a great deal of interest in the dermatology community over the past several years.
The purpose of this article is to review the history of photodynamic therapy in dermatology and to review recent new advances with this technology that will increase its appeal to all dermatologists.
A literature review and results of new clinical trials with regards to photorejuvenation and acne vulgaris treatments with 5-aminolevulinic acid photodynamic therapy are presented.
Short-contact, full-face 5-aminolevulinic acid photodynamic therapy treatments with a variety of lasers and light sources have shown to be successful in treating all facets of photorejuvenation and the associated actinic keratoses as well as disorders of sebaceous glands, including acne vulgaris. The treatments are relatively pain-free, efficacious, and safe. They are also making already available laser/light source therapies work better for acne vulgaris and photorejuvenation.
The use of 5-aminolevulinic acid photodynamic therapy with short-contact, full-face broad-application therapy is now able to bridge the world of medical and cosmetic dermatologic surgery. This therapy is available for all dermatologists to utilize in the care of their patients.
在过去几年中，利用局部应用20%的5-氨基酮戊酸进行的光动力疗法在皮肤科领域引起了广泛关注。
本文旨在回顾光动力疗法在皮肤科的历史，并综述该技术的最新进展，以提高其对所有皮肤科医生的吸引力。
介绍了关于5-氨基酮戊酸光动力疗法用于光嫩肤和寻常痤疮治疗的文献综述及新临床试验结果。
采用多种激光和光源进行的短接触、全脸5-氨基酮戊酸光动力疗法已证明在治疗光嫩肤的各个方面、相关的光化性角化病以及皮脂腺疾病（包括寻常痤疮）方面均取得成功。这些治疗相对无痛、有效且安全。它们还使现有的激光/光源疗法在治疗寻常痤疮和光嫩肤方面效果更佳。
采用短接触、全脸广泛应用疗法的5-氨基酮戊酸光动力疗法如今能够跨越医学和美容皮肤科手术领域。这种疗法可供所有皮肤科医生用于治疗他们的患者。
