Dikshit Rajesh P, Ramadas K, Hashibe Mia, Thomas Gigi, Somanathan Thara, Sankaranarayanan R
Gene Environment Epidemiology Group, International Agency for Research on Cancer, Lyon, France.
Int J Cancer. 2006 Jan 15;118(2):453-7. doi: 10.1002/ijc.21345.
Recent studies have suggested role of diabetes mellitus in the development of periodontal diseases, oral inflammatory and neoplastic lesions. We analysed data from randomised oral cancer screening trial in Kerala, India, to study the association between chronic diseases in general, diabetes mellitus in particular, and pre-malignant oral lesions and conditions. A total of 927 subjects with oral leukoplakia, 170 with oral submucous fibrosis, 100 with erythroplakia lesions and 47,773 apparently healthy subjects constituted the cases and controls respectively for our present study. The odds ratio (OR) for oral leukoplakia among women with a history of diabetes mellitus was found to be 2.0 (95% confidence interval (CI) = 1.4-2.9) whereas that for erythroplakia was 3.2 (95% CI = 1.3-7.9), after adjusting for potential confounders. No statistically significant association between diabetes mellitus and oral submucous fibrosis and pre-cancerous lesions/conditions in men was found. An association between diabetes mellitus and pre-malignant oral lesions among women has been observed in our study, although the underlying mechanisms are not clear. This needs to be further evaluated in other settings.
近期研究表明，糖尿病在牙周疾病、口腔炎症及肿瘤性病变的发生发展中起作用。我们分析了印度喀拉拉邦一项随机口腔癌筛查试验的数据，以研究一般慢性疾病，尤其是糖尿病，与口腔癌前病变及状况之间的关联。本研究中，共有927例口腔白斑患者、170例口腔黏膜下纤维化患者、100例红斑患者以及47773例表面健康的受试者分别作为病例组和对照组。在对潜在混杂因素进行校正后，有糖尿病病史的女性患口腔白斑的比值比（OR）为2.0（95%置信区间（CI）=1.4 - 2.9），而患红斑的比值比为3.2（95%CI = 1.3 - 7.9）。未发现糖尿病与男性口腔黏膜下纤维化及癌前病变/状况之间存在统计学显著关联。在我们的研究中，已观察到糖尿病与女性口腔癌前病变之间存在关联，尽管其潜在机制尚不清楚。这需要在其他环境中进一步评估。
