《骨与矿物质研究杂志》周年经典文章。含氮双膦酸盐抑制甲羟戊酸途径，并阻止包括Ras在内的GTP结合蛋白的翻译后异戊二烯化。最初发表于第7卷，第4期，第581 - 589页（1998年）。 - Suppr

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JBMR anniversary classic. Nitrogen-containing biophosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. Originally published in Volume 7, number 4, pp 581-9 (1998).

作者信息

Luckman Steven P, Hughes David E, Coxon Fraser P, Russell Graham G, Rogers Michael J

出版信息

J Bone Miner Res. 2005 Jul;20(7):1265-74. doi: 10.1359/jbmr.2005.20.7.1265.

DOI:10.1359/jbmr.2005.20.7.1265

PMID:16050006

Abstract

摘要

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JBMR anniversary classic. Nitrogen-containing biophosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. Originally published in Volume 7, number 4, pp 581-9 (1998).

作者信息

Luckman Steven P, Hughes David E, Coxon Fraser P, Russell Graham G, Rogers Michael J

出版信息

J Bone Miner Res. 2005 Jul;20(7):1265-74. doi: 10.1359/jbmr.2005.20.7.1265.

DOI:10.1359/jbmr.2005.20.7.1265

PMID:16050006

Abstract

摘要