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Protein prenylation: key to ras function and cancer intervention?

作者信息

Khosravi-Far R, Cox A D, Kato K, Der C J

机构信息

La Jolla Cancer Research Foundation, La Jolla, California 92037.

出版信息

Cell Growth Differ. 1992 Jul;3(7):461-9.

PMID:1419908
Abstract
摘要

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Protein prenylation: key to ras function and cancer intervention?蛋白质异戊二烯化:Ras功能及癌症干预的关键?
Cell Growth Differ. 1992 Jul;3(7):461-9.
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Role of RhoA activation in the growth and morphology of a murine prostate tumor cell line.RhoA激活在小鼠前列腺肿瘤细胞系生长和形态中的作用。
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Ras farnesyltransferase: a new therapeutic target.Ras法尼基转移酶:一个新的治疗靶点。
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The prenylation of proteins.蛋白质的异戊二烯化。
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Specific labeling of isoprenylated proteins: application to study inhibitors of the post-translational farnesylation and geranylgeranylation.异戊二烯化蛋白的特异性标记:用于研究翻译后法尼基化和香叶基香叶基化抑制剂的应用
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Geranylgeranyl diphosphate-based inhibitors of post-translational geranylgeranylation of cellular proteins.
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A yeast GTPase-activating protein that interacts specifically with a member of the Ypt/Rab family.一种与Ypt/Rab家族成员特异性相互作用的酵母GTP酶激活蛋白。
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2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase.作为受限氨基酸的2-取代哌嗪。在法尼基转移酶强效非羧酸抑制剂合成中的应用。
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