Wang P, Tao J Y, Xu S Y
Department of Pharmacology, Fourth Military Medical University, Xi-an, China.
Zhongguo Yao Li Xue Bao. 1992 Jan;13(1):45-7.
Clonidine (1 mg.kg-1, ip) inhibited hemolysis in mice and rats after burn. The effects were abolished by pretreatment with yohimbine (5 mg.kg-1, ip) but not by prazosin (10 mg.kg-1, ip). The increased osmotic fragility of erythrocytes and the elevation of plasma NE level in burned animals were markedly lowered by clonidine which also raised the glutathione level of whole blood and enhanced the activity of glutathione peroxidase. These results indicated that the action of clonidine on hemolysis was carried out by means of depression of adrenergic alpha 2 receptors and reduction of free radicals.
可乐定（1毫克·千克-1，腹腔注射）可抑制烧伤后小鼠和大鼠的溶血。育亨宾（5毫克·千克-1，腹腔注射）预处理可消除该作用，但哌唑嗪（10毫克·千克-1，腹腔注射）预处理则不能。可乐定可显著降低烧伤动物红细胞渗透脆性增加及血浆去甲肾上腺素水平升高的情况，还能提高全血谷胱甘肽水平并增强谷胱甘肽过氧化物酶的活性。这些结果表明，可乐定对溶血的作用是通过抑制肾上腺素能α2受体和减少自由基来实现的。
