Fukushima Chizu, Matsuse Hiroto, Tomari Shinya, Kawano Tetsuya, Matsuo Nobuko, Saeki Sachiko, Asai Sadahiro, Kohno Shigeru
Department of Internal Medicine, Nagasaki Kita Hospital.
Nihon Kokyuki Gakkai Zasshi. 2005 Jul;43(7):396-400.
Using questionnaires for 281 healthy subjects and 139 asthmatic patients in 5 medical institutes, we investigated the relationship between the common cold and acute asthma. The frequency of the common cold, duration to recovery and absences from work were slightly higher in asthmatics than healthy subjects. Acute asthma occurred in a few days following common cold and subsided at the end of or after the common cold. Evaluation of the types of common cold revealed that the cold, which causes upper respiratory symptoms, frequently induced acute asthma. Bronchodilators seemed to be less effective for cold-induced asthma. Collectively, these results suggested that the common cold induces acute asthma not through virus-induced direct inflammatory responses but through indirect immunological responses. Through these questionnaires, we realized that it is important to prevent the common cold, a trigger of asthma attacks. As the guidelines of asthma therapy recommended, the use of corticosteroid must be considered when acute asthma attacks occur.
我们在5家医疗机构对281名健康受试者和139名哮喘患者进行问卷调查，研究普通感冒与急性哮喘之间的关系。哮喘患者的普通感冒频率、恢复时间和缺勤率略高于健康受试者。急性哮喘在普通感冒后几天内发生，并在普通感冒结束时或之后消退。对普通感冒类型的评估显示，引起上呼吸道症状的感冒频繁诱发急性哮喘。支气管扩张剂对感冒诱发的哮喘似乎效果较差。总体而言，这些结果表明，普通感冒诱发急性哮喘并非通过病毒诱导的直接炎症反应，而是通过间接免疫反应。通过这些问卷调查，我们认识到预防作为哮喘发作诱因的普通感冒很重要。正如哮喘治疗指南所推荐的，急性哮喘发作时必须考虑使用皮质类固醇。
