骨骼肌细胞分化过程中的乳酸转运：L6肌管中特定载体的证据。
Lactate transport during differentiation of skeletal muscle cells: evidence for a specific carrier in L6 myotubes.
作者信息
el Abida K, Duvallet A, Thieulart L, Rieu M, Beaudry M
机构信息
Laboratoire de physiologie des adaptations, CHU Cochin, Paris, France.
出版信息
Acta Physiol Scand. 1992 Apr;144(4):469-71. doi: 10.1111/j.1748-1716.1992.tb09322.x.
Abstract
Cellular uptake of lactate involves a carrier in numerous types of mammalian cells. In cultured rat L6 myoblasts, lactate diffuses freely. We show that during myogenesis a carrier appears at the myotube stage. The degree of cellular differentiation was determined by microscopic observation and by measurement of a marker of biochemical differentiation: the increase in specific activity of creatine kinases.
摘要
乳酸的细胞摄取在多种哺乳动物细胞中涉及一种载体。在培养的大鼠L6成肌细胞中，乳酸可自由扩散。我们发现，在肌生成过程中，一种载体在肌管阶段出现。通过显微镜观察以及测量生化分化标志物：肌酸激酶比活性的增加来确定细胞分化程度。
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