Ellingson T L, Wilske K, Aboulafia D M
Department of Internal Medicine, Virginia Mason Medical Center, University of Washington, Seattle.
Am J Med Sci. 1992 Jun;303(6):407-10. doi: 10.1097/00000441-199206000-00012.
Thrombotic thrombocytopenic purpura (TTP) is characterized by the pentad of fever, thrombocytopenia, microangiopathic hemolytic anemia, fluctuating neurologic symptoms, and renal dysfunction. Thrombotic thrombocytopenic purpura has recently been reported in association with rheumatic diseases (RDs). The authors present a patient with TTP and polymyositis and speculate on the pathophysiology linking these two conditions. Thrombotic thrombocytopenic purpura and RDs may present with overlapping clinical and laboratory features. It is important to identify TTP as a cause of thrombocytopenia and hemolysis when occurring in patients with RDs since management, treatment, and prognosis differ. Early recognition and prompt institution of plasmapheresis may improve the outcome in patients with TTP.
血栓性血小板减少性紫癜（TTP）的特征为发热、血小板减少、微血管病性溶血性贫血、波动的神经症状和肾功能不全这五联征。最近有报道称血栓性血小板减少性紫癜与风湿性疾病（RDs）有关。作者介绍了一名患有TTP和多发性肌炎的患者，并推测了将这两种病症联系起来的病理生理学机制。TTP和RDs可能具有重叠的临床和实验室特征。当RDs患者出现血小板减少和溶血时，将TTP识别为其病因很重要，因为管理、治疗和预后有所不同。早期识别并及时进行血浆置换可能会改善TTP患者的预后。
