鼠疫杆菌在感染过程中会攻击免疫细胞。
Plague bacteria target immune cells during infection.
作者信息
Marketon Melanie M, DePaolo R William, DeBord Kristin L, Jabri Bana, Schneewind Olaf
机构信息
Department of Microbiology, University of Chicago, Chicago, IL 60637, USA.
出版信息
Science. 2005 Sep 9;309(5741):1739-41. doi: 10.1126/science.1114580. Epub 2005 Jul 28.
Abstract
The plague is caused by the bacterium Yersinia pestis. Plague bacteria are thought to inject effector Yop proteins into host cells via the type III pathway. The identity of the host cells targeted for injection during plague infection is unknown. We found, using Yop beta-lactamase hybrids and fluorescent staining of live cells from plague-infected animals, that Y. pestis selected immune cells for injection. In vivo, dendritic cells, macrophages, and neutrophils were injected most frequently, whereas B and T lymphocytes were rarely selected. Thus, it appears that Y. pestis disables these cell populations to annihilate host immune responses during plague.
摘要
鼠疫由鼠疫耶尔森菌引起。鼠疫杆菌被认为通过III型分泌系统将效应蛋白Yop注入宿主细胞。在鼠疫感染期间被选为注射目标的宿主细胞的身份尚不清楚。我们使用Yopβ-内酰胺酶杂种和对来自鼠疫感染动物的活细胞进行荧光染色发现，鼠疫耶尔森菌选择免疫细胞进行注射。在体内，树突状细胞、巨噬细胞和中性粒细胞被注射的频率最高，而B淋巴细胞和T淋巴细胞很少被选中。因此，鼠疫耶尔森菌似乎通过使这些细胞群体失去功能来消除鼠疫期间的宿主免疫反应。
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