Green L W
School of Medicine, University of California, San Francisco, CA 94127, USA.
Eur J Clin Nutr. 2005 Aug;59 Suppl 1:S4-8; discussion S9. doi: 10.1038/sj.ejcn.1602167.
A proposal by Wald and Law (2003) for a single pill containing a statin, three half-dose antihypertensives, aspirin, and folic acid, met with a storm of controversy and seemed to have been relegated as much to the fanciful as to the accolades it might have deserved. The benefits such a Polypill could confer on people age 55+y were to reduce both cardiovascular and stroke events by 80% or more. Considering the daunting and, at best, slow process of changing the same risk factors through health promotion interventions on food policy, dietary and physical activity behaviors, and urban planning to make less prevalent the sedentary lifestyles developed over decades, the argument here is to view the Polypill as a harm reduction strategy that would complement health promotion, as Nicotine Replacement Therapy did for tobacco control, seat belts did for traffic injuries, and needle exchange programs did for secondary complications of injection drug use.
沃尔德和劳（2003年）提出了一种包含他汀类药物、三种半剂量抗高血压药物、阿司匹林和叶酸的单片复方制剂，这一提议引发了一场争议风暴，似乎已被归为异想天开之类，尽管它可能值得赞誉。这种复方药物对55岁及以上人群的益处是将心血管事件和中风事件减少80%或更多。考虑到通过促进健康干预措施（如食品政策、饮食和身体活动行为以及城市规划）来改变相同的风险因素，以减少数十年来形成的久坐不动的生活方式，这个过程艰巨且进展缓慢，因此这里的观点是将复方药物视为一种减少危害的策略，它将补充健康促进措施，就像尼古丁替代疗法对烟草控制、安全带对交通伤害、针头交换计划对注射吸毒的继发性并发症所起的作用一样。
