边缘型人格障碍女性患者血小板[3H]帕罗西汀结合受损。
Impaired platelet [3H]paroxetine binding in female patients with borderline personality disorder.
作者信息
Ng Ying Kin N M K, Paris Joel, Schwartz George, Zweig-Frank Hallie, Steiger Howard, Nair N P V
机构信息
Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
出版信息
Psychopharmacology (Berl). 2005 Nov;182(3):447-51. doi: 10.1007/s00213-005-0097-1. Epub 2005 Oct 19.
RATIONALE
There have been few studies of platelet paroxetine binding in borderline personality disorder (BPD).
OBJECTIVE
Our aim was to determine whether female BPD subjects show abnormalities in platelet paroxetine binding.
METHODS
Twenty-one female BPD subjects and 16 age- and gender-matched normal control subjects were assessed using the following: (1) Diagnostic Interview for Borderlines, Revised, (2) Diagnostic Assessment for Personality Pathology: Brief Questionnaire, and (3) Barratt Impulsivity Scale. Platelets were collected and assayed for platelet paroxetine binding.
RESULTS
Bmax was lower in the BPD group (p < 0.0001), but differences in Kd only reached a trend level. There were no associations with trait dimensions independent of diagnosis.
CONCLUSIONS
Reduced platelet paroxetine binding in female BPD patients may reflect presynaptic serotonin dysfunction.
理论依据
关于边缘型人格障碍（BPD）患者血小板中帕罗西汀结合情况的研究较少。
目的
我们的目的是确定女性BPD患者血小板中帕罗西汀结合是否存在异常。
方法
使用以下方法对21名女性BPD患者和16名年龄及性别匹配的正常对照者进行评估：（1）修订版边缘型人格障碍诊断访谈，（2）人格病理学诊断评估：简短问卷，（3）巴拉特冲动量表。采集血小板并检测血小板中帕罗西汀的结合情况。
结果
BPD组的最大结合容量（Bmax）较低（p < 0.0001），但解离常数（Kd）的差异仅达到趋势水平。与诊断无关的特质维度无相关性。
结论
女性BPD患者血小板中帕罗西汀结合减少可能反映突触前5-羟色胺功能障碍。
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