Csécsei K, Kovács T, Hinchliffe S A, Papp Z
Department of Obstetrics and Gynaecology, University Medical School, Debrecen, Hungary.
Am J Med Genet. 1992 Jun 1;43(3):524-30. doi: 10.1002/ajmg.1320430305.
The absence of one umbilical artery (SUA) is the most common malformation of the umbilical cord. It may accompany other abnormalities or occur as an isolated defect. We examined 885 fetuses, terminated following the prenatal diagnosis of serious or lethal malformations between April 1977 and March 1989, for the presence of SUA. We found 62 cases of SUA. This represents an incidence of 7.01% (62/885). The most common abnormalities found in association with SUA were: (1) multiple malformations (8/11 cases, SUA incidence = 72.7%), (2) ADAM complex (7/14 cases, SUA incidence = 50.%), (3) multicystic renal dysplasia (5/20 cases, SUA incidence = 25.%), and (4) Potter sequence (5/21 cases, SUA incidence = 23.8%). These associations have not been documented previously. In 6 fetuses the Meckel syndrome was diagnosed, and SUA was present in 2 of these. Therefore, SUA may represent an additional anomaly in Meckel syndrome that has not been reported previously.
单脐动脉（SUA）是脐带最常见的畸形。它可能伴有其他异常，也可能作为孤立缺陷出现。我们检查了1977年4月至1989年3月期间因产前诊断出严重或致命畸形而终止妊娠的885例胎儿，以确定是否存在SUA。我们发现62例SUA。这代表发病率为7.01%（62/885）。与SUA相关的最常见异常为：（1）多发畸形（8/11例，SUA发病率 = 72.7%），（2）ADAM综合征（7/14例，SUA发病率 = 50%），（3）多囊性肾发育不良（5/20例，SUA发病率 = 25%），以及（4）波特序列征（5/21例，SUA发病率 = 23.8%）。这些关联以前尚未有文献记载。在6例胎儿中诊断出梅克尔综合征，其中2例存在SUA。因此，SUA可能是梅克尔综合征中一种以前未报道过的额外异常。
