Kapić Elvedina, Becić Fahir, Todić Maida
Institute for Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Sarajevo, Cekalusa 90, 71 000 Sarajevo, Bosnia and Herzegovina.
Bosn J Basic Med Sci. 2005 May;5(2):38-42. doi: 10.17305/bjbms.2005.3282.
In this paper we have reviewed the position of desmopressin in the treatment of diabetes insipidus. Desmopressin is a synthetic analog of vasopressin, with more pronounced antidiuretic effect. It is treatment of choice in substitution therapy of diabetes insipidus. Its application before sleeping time can reduce nocturnal enuresis, so it has a place in the treatment of enuresis nocturna. Antidiuretic effect of desmopressin is the result of agonistic effect on V2 receptors in the renal tubules. The efficacy and safety of desmopressin in mentioned indications was confirmed in clinical studies.
在本文中，我们回顾了去氨加压素在治疗尿崩症中的地位。去氨加压素是血管加压素的合成类似物，具有更显著的抗利尿作用。它是尿崩症替代治疗的首选药物。睡前使用可减少夜间遗尿，因此在治疗夜间遗尿方面也有一席之地。去氨加压素的抗利尿作用是对肾小管V2受体激动作用的结果。临床研究证实了去氨加压素在上述适应症中的疗效和安全性。
