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自膨式金属支架治疗恶性吞咽困难:100例连续患者的疗效分析

Self-expanding metal stents in the palliation of malignant dysphagia: outcome analysis in 100 consecutive patients.

作者信息

Elphick D A, Smith B A, Bagshaw J, Riley S A

机构信息

Department of Gastroenterology, Northern General Hospital, Herries Road, Sheffield, UK.

出版信息

Dis Esophagus. 2005;18(2):93-5. doi: 10.1111/j.1442-2050.2005.00458.x.

Abstract

SUMMARY. Patients with inoperable esophageal malignancy often undergo palliative self-expanding metal stent insertion. This analysis of cases shows that although such stents provide good palliation of dysphagia, complications frequently occur. Complications reported were pain after insertion, bleeding, food bolus impaction, stent migration and increased gastroesophageal reflux. Furthermore, in patients with esophageal adenocarcinoma, survival was less if the distal end of the stent entered the stomach, rather than lying entirely within the esophagus. Reduced survival, in this group with gastroesophageal junction tumors, may be a result of increased gastroesophageal reflux leading to pulmonary aspiration. Stents incorporating an antireflux valve have been shown to reduce symptomatic gastroesophageal reflux. It may be that such valves offer a survival advantage where stent insertion ablates the function of the lower esophageal sphincter. Further studies are needed to assess the role of antireflux stents on survival in patients with gastroesophageal junction tumors.

摘要

摘要。无法手术的食管恶性肿瘤患者常接受姑息性自膨式金属支架置入术。对病例的分析表明,尽管此类支架能有效缓解吞咽困难,但并发症却频繁发生。报告的并发症有置入后疼痛、出血、食物团块嵌塞、支架移位以及胃食管反流增加。此外,在食管腺癌患者中,如果支架远端进入胃内而非完全位于食管内,其生存期会缩短。在这组胃食管交界部肿瘤患者中,生存期缩短可能是由于胃食管反流增加导致肺误吸所致。已证实带有抗反流瓣膜的支架可减少有症状的胃食管反流。在支架置入使食管下括约肌功能丧失的情况下,此类瓣膜可能具有生存优势。需要进一步研究来评估抗反流支架在胃食管交界部肿瘤患者生存中的作用。

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