Gonzalez Frank J
Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Building 37, Room 3106, Bethesda, Maryland 20892, USA.
Cell Metab. 2005 Feb;1(2):85-6. doi: 10.1016/j.cmet.2005.01.004.
A transcription factor cascade drives adipogenesis. Two new members of this cascade have been uncovered--Kruppel-like factor 5 (KLF5), which is induced by C/EBPbeta and delta and acts in concert with C/EBPalpha, beta, and delta to activate PPARgamma2 expression, and Krox20, which is upstream of C/EBPbeta expression and one of the earliest factors induced during adipogenesis.
转录因子级联反应驱动脂肪生成。该级联反应的两个新成员已被发现——Kruppel样因子5（KLF5），它由C/EBPβ和δ诱导，并与C/EBPα、β和δ协同作用以激活PPARγ2的表达；以及Krox20，它位于C/EBPβ表达的上游，是脂肪生成过程中最早诱导产生的因子之一。
