组胺H4受体作为炎症的新治疗靶点。
The histamine H4 receptor as a new therapeutic target for inflammation.
作者信息
de Esch Iwan J P, Thurmond Robin L, Jongejan Aldo, Leurs Rob
机构信息
Leiden/Amsterdam Center for Drug Research, Department of Medicinal Chemistry, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.
出版信息
Trends Pharmacol Sci. 2005 Sep;26(9):462-9. doi: 10.1016/j.tips.2005.07.002.
Following the sequencing of the human genome, data-mining efforts have revealed the existence of a new histamine receptor that is expressed at high levels in mast cells and leukocytes. The histamine H(4) receptor has a distinct pharmacological profile and the first compounds that act selectively on the H(4) receptor have been developed. Initial experiments in vivo with H(4) receptor antagonists indicate a role for the H(4) receptor in inflammatory conditions.
随着人类基因组测序工作的完成，数据挖掘工作揭示了一种新的组胺受体的存在，该受体在肥大细胞和白细胞中高水平表达。组胺H4受体具有独特的药理学特性，并且已经开发出了首批选择性作用于H4受体的化合物。最初使用H4受体拮抗剂进行的体内实验表明，H4受体在炎症状态中发挥作用。
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