Ferrand Audrey, Wang Timothy C
IFR31, Institut Louis Bugnard, BP 84225, Unité INSERM 531, Biologie et Pathologie Digestives, 31432 TOULOUSE, Cedex 4, France.
Cancer Lett. 2006 Jul 8;238(1):15-29. doi: 10.1016/j.canlet.2005.06.025. Epub 2005 Jul 27.
In 1905, a Cambridge physiologist, John Sydney Edkins, initially identified a hormone responsible of gastric acid secretion, which he called gastric secretin, or gastrin. While gastrin's role in acid secretion is now well defined, more recent studies have implicated the various isoforms of gastrin in cancer. Important advances in the last decade have included the recognition of biological activity for processing intermediates such as progastrin and the glycine-extended gastrin. Here, we give an overview of the roles of these peptides in cancer, highlighted by molecular, cellular and integrated studies on animal models for progastrin-derived peptides and their receptors.
1905年，剑桥大学的生理学家约翰·悉尼·埃金斯首次发现了一种负责胃酸分泌的激素，他将其称为胃泌素或促胃液素。虽然胃泌素在胃酸分泌中的作用现已明确，但最近的研究表明胃泌素的各种同工型与癌症有关。过去十年的重要进展包括认识到前胃泌素和甘氨酸延伸胃泌素等加工中间体的生物活性。在此，我们概述这些肽在癌症中的作用，重点介绍对前胃泌素衍生肽及其受体的动物模型进行的分子、细胞和综合研究。
