Sawada M, Dickinson C J
University of Michigan Medical Center, Ann Arbor 48109-0658, USA.
Annu Rev Physiol. 1997;59:273-98. doi: 10.1146/annurev.physiol.59.1.273.
The study of gastrin continues to serve as an excellent model for gastrointestinal regulatory processes. This review highlights some recent advances in the field by outlining gastrin biosynthesis, summarizing current understanding of gastrin receptors, describing the regulation of gastrin release, and discussing the clinical implications of gastrin in the pathogenesis of peptic ulcer disease. Emphasis is on three emerging areas of gastrin research: the novel finding that one of gastrin's posttranslational processing intermediates has biological activity distinct from that of the mature peptide; elucidation of gastrin's signal transduction mechanisms that mediate the trophic effects of the peptide; and the role of gastrin in peptic ulcer disease pathogenesis secondary to Helicobacter pylori infection.
胃泌素的研究一直是胃肠调节过程的优秀模型。本综述通过概述胃泌素的生物合成、总结目前对胃泌素受体的认识、描述胃泌素释放的调节以及讨论胃泌素在消化性溃疡病发病机制中的临床意义，突出了该领域的一些最新进展。重点关注胃泌素研究中三个新出现的领域：一个新发现，即胃泌素翻译后加工中间体之一具有与成熟肽不同的生物活性；阐明介导该肽营养作用的胃泌素信号转导机制；以及胃泌素在幽门螺杆菌感染继发的消化性溃疡病发病机制中的作用。
