新型HIV-1 Tat-TAR相互作用拟肽抑制剂的设计与合成：方酰二胺作为未取代胍的新型潜在生物电子等排体

Design and synthesis of a novel peptidomimetic inhibitor of HIV-1 Tat-TAR interactions: squaryldiamide as a new potential bioisostere of unsubstituted guanidine.

作者信息

Lee Chi-Wan, Cao Hong, Ichiyama Kozi, Rana Tariq M

机构信息

Chemical Biology Program, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605-2324, USA.

出版信息

Bioorg Med Chem Lett. 2005 Oct 1;15(19):4243-6. doi: 10.1016/j.bmcl.2005.06.077.

DOI:10.1016/j.bmcl.2005.06.077

PMID:16054360

Abstract

By performing RNA-targeted structure-activity relationship studies, we discovered a novel peptidomimetic containing squaryldiamide as a potential bioisostere replacement for guanidine that binds transactivation responsive RNA with high affinity.

摘要

通过进行RNA靶向的构效关系研究，我们发现了一种含有方酸二酰胺的新型拟肽，它作为胍的潜在生物电子等排体替代物，能以高亲和力结合反式激活响应RNA。

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新型HIV-1 Tat-TAR相互作用拟肽抑制剂的设计与合成：方酰二胺作为未取代胍的新型潜在生物电子等排体

Design and synthesis of a novel peptidomimetic inhibitor of HIV-1 Tat-TAR interactions: squaryldiamide as a new potential bioisostere of unsubstituted guanidine.

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新型HIV-1 Tat-TAR相互作用拟肽抑制剂的设计与合成：方酰二胺作为未取代胍的新型潜在生物电子等排体

Design and synthesis of a novel peptidomimetic inhibitor of HIV-1 Tat-TAR interactions: squaryldiamide as a new potential bioisostere of unsubstituted guanidine.

作者信息

机构信息

出版信息

相似文献

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