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加那利群岛特有物种苏斯库勒蒿的利尿活性。

Diuretic activity of Artemisia thuscula, an endemic Canary species.

作者信息

Benjumea D, Abdala S, Hernandez-Luis F, Pérez-Paz P, Martin-Herrera D

机构信息

Unidad de Farmacología y Farmacognosia, Facultad de Farmacia, Universidad de La Laguna, 38207, La Laguna, Canary Islands, Spain.

出版信息

J Ethnopharmacol. 2005 Aug 22;100(1-2):205-9. doi: 10.1016/j.jep.2005.03.005.

Abstract

A pharmacological evaluation for diuretic activity of infusions at 5, 10 and 15% of Artemisia thuscula Cav. was carried out. Urinary excretion of water, pH, density, conductivity and Na(+), K(+) and Cl(-) content were investigated in saline-loaded rats. The infusions showed a dose-dependent decrease diuretic effect, but augmented significantly with respect to the control group for the urinary excretion of water and sodium. Furthermore, a potassium-sparing effect at 5 and 10% was showed. The diuretic effect does not seem to be related to the potassium content of the starting material. The results justify the use of Artemisia thuscula as diuretic agent by the canary traditional medicine.

摘要

对5%、10%和15%的苏氏蒿(Artemisia thuscula Cav.)浸剂的利尿活性进行了药理学评价。在盐水负荷大鼠中研究了水的尿排泄、pH值、密度、电导率以及Na(+)、K(+)和Cl(-)含量。浸剂呈现出剂量依赖性的利尿作用减弱,但水和钠的尿排泄相对于对照组显著增加。此外,5%和10%的浸剂显示出保钾作用。利尿作用似乎与起始原料的钾含量无关。这些结果证明了加那利传统医学将苏氏蒿用作利尿剂的合理性。

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