低级别B细胞非霍奇金淋巴瘤中LEF-1 mRNA表达的变化

Variation of LEF-1 mRNA expression in low-grade B-cell non-Hodgkin's lymphoma.

作者信息

Howe Denise, Bromidge Teresa

机构信息

Leukaemia Research Laboratory, Taunton & Somerset NHS Trust, Musgrove Park Hospital, Taunton, Somerset TA1 5DA, UK.

出版信息

Leuk Res. 2006 Jan;30(1):29-32. doi: 10.1016/j.leukres.2005.06.004. Epub 2005 Jul 28.

DOI:10.1016/j.leukres.2005.06.004

PMID:16054689

Abstract

During normal B-lymphocyte development once cells pass the pro-B stage the transcription factor LEF-1, a key component of the Wnt/beta-catenin pathway, is down regulated. However studies have shown that B-cell chronic lymphocytic leukaemia (CLL) lymphocytes, which have a mature B-cell phenotype, still express abundant LEF-1. This study demonstrates that although LEF-1 mRNA is universally, highly expressed in B-CLL, expression of this gene is much lower or absent in the majority of low-grade B-cell non-Hodgkin's lymphoma (NHL). This suggests that there exist key differences in the activity of the Wnt/beta-catenin pathway between low-grade B-cell malignancies.

摘要

在正常B淋巴细胞发育过程中，一旦细胞通过前B细胞阶段，转录因子LEF-1（Wnt/β-连环蛋白信号通路的关键组成部分）的表达就会下调。然而，研究表明，具有成熟B细胞表型的B细胞慢性淋巴细胞白血病（CLL）淋巴细胞仍大量表达LEF-1。本研究表明，尽管LEF-1 mRNA在B-CLL中普遍且高度表达，但该基因在大多数低级别B细胞非霍奇金淋巴瘤（NHL）中的表达要低得多或不存在。这表明低级别B细胞恶性肿瘤之间Wnt/β-连环蛋白信号通路的活性存在关键差异。