7价肺炎球菌CRM197结合疫苗在有症状的HIV-1感染儿童中诱导的免疫原性和免疫记忆。
Immunogenicity and immunological memory induced by a 7-valent pneumococcal CRM197 conjugate vaccine in symptomatic HIV-1 infected children.
作者信息
Spoulou Vana I, Tsoumas Dimitris L, Papaevangelou Vana G, Mostrou Glykeria I, Theodoridou Maria C
机构信息
1st Department of Pediatrics, Division of Infectious Diseases, Aghia Sophia Children's Hospital, Athens University School of Medicine, Thivon and M. Asias St., Goudi 11527, Athens, Greece.
出版信息
Vaccine. 2005 Nov 16;23(46-47):5289-93. doi: 10.1016/j.vaccine.2005.06.002. Epub 2005 Jun 21.
A 7-valent CRM197 conjugate pneumococcal vaccine (PCV)-induced immune response were evaluated in all Greek symptomatic HIV-1 infected children and 21 age-matched controls. PCV immunogenicity was inferior in HIV patients compared with the controls although differences in geometric mean concentrations (GMC) were not significant (P>.05). Immune responses were strikingly different after anamnestic immunization, given in all study subjects, 12 months later. HIV-positive children achieved lower GMC for all serotypes compared with the controls (P=.002) and avidity for all except serotype 6B was inferior compared to baseline. Long-term PCV effectiveness is expected to be reduced among symptomatic HIV-1 infected children.
在所有有症状的希腊HIV-1感染儿童和21名年龄匹配的对照中评估了7价CRM197结合肺炎球菌疫苗（PCV）诱导的免疫反应。尽管几何平均浓度（GMC）差异不显著（P>0.05），但与对照组相比，HIV患者中PCV的免疫原性较差。在12个月后对所有研究对象进行回忆免疫后，免疫反应有显著差异。与对照组相比，HIV阳性儿童所有血清型的GMC较低（P=0.002），除6B血清型外，所有血清型的亲和力均低于基线。预计在有症状的HIV-1感染儿童中，PCV的长期有效性会降低。
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